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· 7 0 · 微生物学免疫学进展 2016 年 2 月第 44 卷第 1 期 Prog in Microbiol Immunol,Feb. 2016, Vol. 44 No. 1
致病机制的进一步研究和探索,以及新型佐剂和疫 [J]. PLoS One, 2010,5(10):e13171-e13180.
苗接种途径的不断问世,相信预防和治疗衣原体感 [13] Pal S, Theodor I, Peterson EM, et al. Immunization with the
Chlamydia trachomatis mouse pneumonitis major outer membrane
染的疫苗会很快实现。
protein can elicit a protective immune response against a genital
challenge[J]. Infect Immun, 2001,69(10):6240-6247.
参考文献 [14] Vasilevsky S, Greub G, Nardelli-Haefliger D, et al. Genital
Chlamydia trachomatis: understanding the roles of innate and a-
[1] Bachmann NL, Polkinghorne A, Timms P. Chlamydia genomics: daptive immunity in vaccine research[ J]. Clin Microbiol Rev,
providing novel insights into chlamydial biology[J]. Trends Micro- 2014,27(2):346-370.
biol, 2014,22(8):464-472. [15] Cheng C, Pal S, Bettahi I, et al. Immunogenicity of a vaccine
[2] Schautteet K, De Clercq E, Vanrompay D. Chlamydia trachomatis formulated with the Chlamydia trachomatis serovar F, native ma-
vaccine research through the years[J]. Infect Dis Obstet Gynecol, jor outer membrane protein in a nonhuman primate model[ J].
2011,2011:1-9. Vaccine, 2011,29(18):3456-3464.
[3] Hanley KA. The double-edged sword: How evolution can make or [16] Yu H, Karunakaran KP, Jiang X, et al. Chlamydia muridarum T
break a live-attenuated virus vaccine[J]. Evolution (NY), 2011, cell antigens and adjuvants that induce protective immunity in
4(4):635-643. mice[J]. Infect Immun, 2012,80(4):1510-1518.
[4] Chen C,Zhou Z, Conrad T, et al. In vitro passage selects for [17] Tan C, Hsia RC, Shou H, et al. Chlamydia trachomatis-infected
Chlamydia muridarum with enhanced infectivity in cultured cells patients display variable antibody profiles against the nine-mem-
but attenuated pathogenicity in mouse upper genital tract[J]. In- ber polymorphic membrane protein family [ J]. Infect Immun,
fect Immun, 2015,83(5):1881-1892. 2009,77(8):3218-3226.
[5] Liu Y, Huang Y, Yang Z, et al. Plasmid-encoded Pgp3 is a ma- [18] Wang J, Chen L, Chen F, et al. A chlamydial type III-secreted
jor virulence factor for Chlamydia muridarum to induce hydrosal- effector protein (Tarp) is predominantly recognized by antibodies
pinx in mice[J]. Infect Immun, 2014,82(12):5327-5335. from humans infected with Chlamydia trachomatis and induces
[6] O'Connell CM, Ingalls RR, Andrews CW Jr, et al. Plasmid-defi- protective immunity against upper genital tract pathologies in mice
cient Chlamydia muridarum fail to induce immune pathology and [J]. Vaccine, 2009,27(22):2967-2980.
protect against oviduct disease[ J]. J Immunol, 2007,179 (6): [19] Murthy AK, Li W, Guentzel MN, et al. Vaccination with the de-
4027-4034. fined chlamydial secreted protein CPAF induces robust protection
[7] Olivares-Zavaleta N, Whitmire W, Gardner D, et al. Immuniza- against female infertility following repeated genital chlamydial
tion with the attenuated plasmidless Chlamydia trachomatis L2 challenge[J]. Vaccine, 2011,29(14):2519-2522.
(25667R) strain provides partial protection in a murine model of [20] 陆春雪,吴移谋,彭波,等. 沙眼衣原体分泌性蛋白 Pgp3 滴鼻
female genitourinary tract infection[ J]. Vaccine, 2010,28 (6): 免疫增强小鼠对衣原体生殖道感染的保护作用[ J]. 微生物
1454-1462. 学通报, 2012,39(2):226-236.
[8] Kari L, Whitmire WM, Olivares-Zavaleta N, et al. A live-attenu- [21] Zhang D, Yang X, Shen C, et al. Priming with Chlamydia tra-
ated chlamydial vaccine protects against trachoma in nonhuman chomatis major outer membrane protein (MOMP) DNA followed
primates[J]. J Exp Med, 2011,208(11):2217-2223. by MOMP ISCOM boosting enhances protection and is associated
[9] Yu H, Karunakaran KP, Kelly I, et al. Immunization with live with increased immunoglobulin A and Th1 cellular immune re-
and dead Chlamydia muridarum induces different levels of protec- sponses[J]. Infect Immun, 2000,68(6):3074-3078.
tive immunity in a murine genital tract model: correlation with [22] Schautteet K, De Clercq E, Jonsson Y, et al. Protection of pigs
MHC class II peptide presentation and multifunctional Th1 cells against genital Chlamydia trachomatis challenge by parenteral or
[J]. J Immunol, 2011,186(6):3615-3621. mucosal DNA immunization[J]. Vaccine, 2012,30(18):2869-
+
[10] Olivares-Zavaleta N, Whitmire WM, Kari L, et al. CD8 T cells 2881.
define an unexpected role in live-attenuated vaccine protective [23] Ou C, Tian D, Ling Y, et al. Evaluation of an ompA-based
immunity against Chlamydia trachomatis infection in macaques phage-mediated DNA vaccine against Chlamydia abortus in pig-
[J]. J Immunol, 2014,192(10):4648-4654. lets[J]. Int Immunopharmacol, 2013,16(4):505-510.
[11] Olsen AW, Follmann F, Erneholm K, et al. Protection against [24] Xu W, Liu J, Gong W, et al. Protective immunity against
chlamydia trachomatis infection and upper genital tract pathologi- Chlamydia trachomatis genital infection induced by a vaccine
cal changes by vaccine-promoted neutralizing antibodies directed based on the major outer membrane multi-epitope human papillo-
to the VD4 of the major outer membrane protein [ J]. J Infect mavirus major capsid protein L1[ J]. Vaccine, 2011,29(15):
Dis, 2015,212(5):1-12. 2672-2678.
[12] Nunes A, Nogueira PJ, Borrego MJ, et al. Adaptive evolution of [25] Li Z, Wang S, Wu Y, et al. Immunization with chlamydial plas-
the Chlamydia trachomatis dominant antigen reveals distinct evo- mid protein pORF5 DNA vaccine induces protective immunity a-
lutionary scenarios for B- and T-cell epitopes: worldwide survey gainst genital chlamydial infection in mice[J]. Sci China C Life
致病机制的进一步研究和探索,以及新型佐剂和疫 [J]. PLoS One, 2010,5(10):e13171-e13180.
苗接种途径的不断问世,相信预防和治疗衣原体感 [13] Pal S, Theodor I, Peterson EM, et al. Immunization with the
Chlamydia trachomatis mouse pneumonitis major outer membrane
染的疫苗会很快实现。
protein can elicit a protective immune response against a genital
challenge[J]. Infect Immun, 2001,69(10):6240-6247.
参考文献 [14] Vasilevsky S, Greub G, Nardelli-Haefliger D, et al. Genital
Chlamydia trachomatis: understanding the roles of innate and a-
[1] Bachmann NL, Polkinghorne A, Timms P. Chlamydia genomics: daptive immunity in vaccine research[ J]. Clin Microbiol Rev,
providing novel insights into chlamydial biology[J]. Trends Micro- 2014,27(2):346-370.
biol, 2014,22(8):464-472. [15] Cheng C, Pal S, Bettahi I, et al. Immunogenicity of a vaccine
[2] Schautteet K, De Clercq E, Vanrompay D. Chlamydia trachomatis formulated with the Chlamydia trachomatis serovar F, native ma-
vaccine research through the years[J]. Infect Dis Obstet Gynecol, jor outer membrane protein in a nonhuman primate model[ J].
2011,2011:1-9. Vaccine, 2011,29(18):3456-3464.
[3] Hanley KA. The double-edged sword: How evolution can make or [16] Yu H, Karunakaran KP, Jiang X, et al. Chlamydia muridarum T
break a live-attenuated virus vaccine[J]. Evolution (NY), 2011, cell antigens and adjuvants that induce protective immunity in
4(4):635-643. mice[J]. Infect Immun, 2012,80(4):1510-1518.
[4] Chen C,Zhou Z, Conrad T, et al. In vitro passage selects for [17] Tan C, Hsia RC, Shou H, et al. Chlamydia trachomatis-infected
Chlamydia muridarum with enhanced infectivity in cultured cells patients display variable antibody profiles against the nine-mem-
but attenuated pathogenicity in mouse upper genital tract[J]. In- ber polymorphic membrane protein family [ J]. Infect Immun,
fect Immun, 2015,83(5):1881-1892. 2009,77(8):3218-3226.
[5] Liu Y, Huang Y, Yang Z, et al. Plasmid-encoded Pgp3 is a ma- [18] Wang J, Chen L, Chen F, et al. A chlamydial type III-secreted
jor virulence factor for Chlamydia muridarum to induce hydrosal- effector protein (Tarp) is predominantly recognized by antibodies
pinx in mice[J]. Infect Immun, 2014,82(12):5327-5335. from humans infected with Chlamydia trachomatis and induces
[6] O'Connell CM, Ingalls RR, Andrews CW Jr, et al. Plasmid-defi- protective immunity against upper genital tract pathologies in mice
cient Chlamydia muridarum fail to induce immune pathology and [J]. Vaccine, 2009,27(22):2967-2980.
protect against oviduct disease[ J]. J Immunol, 2007,179 (6): [19] Murthy AK, Li W, Guentzel MN, et al. Vaccination with the de-
4027-4034. fined chlamydial secreted protein CPAF induces robust protection
[7] Olivares-Zavaleta N, Whitmire W, Gardner D, et al. Immuniza- against female infertility following repeated genital chlamydial
tion with the attenuated plasmidless Chlamydia trachomatis L2 challenge[J]. Vaccine, 2011,29(14):2519-2522.
(25667R) strain provides partial protection in a murine model of [20] 陆春雪,吴移谋,彭波,等. 沙眼衣原体分泌性蛋白 Pgp3 滴鼻
female genitourinary tract infection[ J]. Vaccine, 2010,28 (6): 免疫增强小鼠对衣原体生殖道感染的保护作用[ J]. 微生物
1454-1462. 学通报, 2012,39(2):226-236.
[8] Kari L, Whitmire WM, Olivares-Zavaleta N, et al. A live-attenu- [21] Zhang D, Yang X, Shen C, et al. Priming with Chlamydia tra-
ated chlamydial vaccine protects against trachoma in nonhuman chomatis major outer membrane protein (MOMP) DNA followed
primates[J]. J Exp Med, 2011,208(11):2217-2223. by MOMP ISCOM boosting enhances protection and is associated
[9] Yu H, Karunakaran KP, Kelly I, et al. Immunization with live with increased immunoglobulin A and Th1 cellular immune re-
and dead Chlamydia muridarum induces different levels of protec- sponses[J]. Infect Immun, 2000,68(6):3074-3078.
tive immunity in a murine genital tract model: correlation with [22] Schautteet K, De Clercq E, Jonsson Y, et al. Protection of pigs
MHC class II peptide presentation and multifunctional Th1 cells against genital Chlamydia trachomatis challenge by parenteral or
[J]. J Immunol, 2011,186(6):3615-3621. mucosal DNA immunization[J]. Vaccine, 2012,30(18):2869-
+
[10] Olivares-Zavaleta N, Whitmire WM, Kari L, et al. CD8 T cells 2881.
define an unexpected role in live-attenuated vaccine protective [23] Ou C, Tian D, Ling Y, et al. Evaluation of an ompA-based
immunity against Chlamydia trachomatis infection in macaques phage-mediated DNA vaccine against Chlamydia abortus in pig-
[J]. J Immunol, 2014,192(10):4648-4654. lets[J]. Int Immunopharmacol, 2013,16(4):505-510.
[11] Olsen AW, Follmann F, Erneholm K, et al. Protection against [24] Xu W, Liu J, Gong W, et al. Protective immunity against
chlamydia trachomatis infection and upper genital tract pathologi- Chlamydia trachomatis genital infection induced by a vaccine
cal changes by vaccine-promoted neutralizing antibodies directed based on the major outer membrane multi-epitope human papillo-
to the VD4 of the major outer membrane protein [ J]. J Infect mavirus major capsid protein L1[ J]. Vaccine, 2011,29(15):
Dis, 2015,212(5):1-12. 2672-2678.
[12] Nunes A, Nogueira PJ, Borrego MJ, et al. Adaptive evolution of [25] Li Z, Wang S, Wu Y, et al. Immunization with chlamydial plas-
the Chlamydia trachomatis dominant antigen reveals distinct evo- mid protein pORF5 DNA vaccine induces protective immunity a-
lutionary scenarios for B- and T-cell epitopes: worldwide survey gainst genital chlamydial infection in mice[J]. Sci China C Life
